Origin-Dependent Inverted-Repeat Amplification: Tests of a Model for Inverted DNA Amplification
نویسندگان
چکیده
منابع مشابه
Origin-Dependent Inverted-Repeat Amplification: Tests of a Model for Inverted DNA Amplification.
DNA replication errors are a major driver of evolution--from single nucleotide polymorphisms to large-scale copy number variations (CNVs). Here we test a specific replication-based model to explain the generation of interstitial, inverted triplications. While no genetic information is lost, the novel inversion junctions and increased copy number of the included sequences create the potential fo...
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Models proposed to explain the generation of palindromic (or quasipalindromic) structures during segmental amplification almost invariably begin with doublestranded DNA breaks that are repaired in different ways—for example, by end-toend fusion at short inverted repeats, by non-allelic homologous recombination at low copy repeats, or by break-induced replication at regions of microhomology. How...
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Inverted repeats are important genetic elements for genome instability. In the current study we have investigated the role of inverted repeats in a DNA rearrangement reaction using a linear DNA substrate. We show that linear DNA substrates with terminal inverted repeats can efficiently transform Escherichia coli. The transformation products contain circular inverted dimers in which the DNA sequ...
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– We investigate the propagation of a coherent probe light pulse through a threelevel atomic medium (in the Λ–configuration) in the presence of a pump laser under the conditions for gain without inversion. When the carrier frequency of the probe pulse and the pump laser are in a Raman configuration, we show that it is possible to amplify a slow propagating pulse. We also analyze the regime in w...
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ژورنال
عنوان ژورنال: PLOS Genetics
سال: 2015
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1005699